Broccoli sprout beverage enhances detoxification of air pollutants in clinical trial
A clinical trial involving nearly 300 Chinese men and women residing in one of China’s most polluted regions found that daily consumption of a half cup of broccoli sprout beverage produced rapid, significant and sustained higher levels of excretion of benzene, a known human carcinogen, and acrolein, a lung irritant. Researchers from the Johns Hopkins Bloomberg School of Public Health, working with colleagues at several U.S. and Chinese institutions, used the broccoli sprout beverage to provide sulforaphane, a plant compound already demonstrated to have cancer preventive properties in animal studies.
The study was published in the June 9 online edition of the journal Cancer Prevention Research.
"Air pollution is a complex and pervasive public health problem," notes John Groopman, PhD, Anna M. Baetjer Professor of Environmental Health at the Johns Hopkins Bloomberg School of Public Health and one of the study’s co-authors. "To address this problem comprehensively, in addition to the engineering solutions to reduce regional pollution emissions, we need to translate our basic science into strategies to protect individuals from these exposures. This study supports the development of food-based strategies as part of this overall prevention effort."
P. A. Egner, J. G. Chen, A. T. Zarth, D. Ng, J. Wang, K. H. Kensler, L. P. Jacobson, A. Munoz, J. L. Johnson, J. D. Groopman, J. W. Fahey, P. Talalay, J. Zhu, T.-Y. Chen, G.-S. Qian, S. G. Carmella, S. S. Hecht, T. W. Kensler. Rapid and Sustainable Detoxication of Airborne Pollutants by Broccoli Sprout Beverage: Results of a Randomized Clinical Trial in China. Cancer Prevention Research, 2014; DOI: 10.1158/1940-6207.CAPR-14-0103